Diarrhea Medication: What You Need to Know

Got the runs and wondering if a pill can help? Diarrhea can strike anyone, and knowing which medication works best saves you time and discomfort. Below you’ll get the basics on over‑the‑counter (OTC) choices, prescription options, proper dosing, and safety tips you can apply right away.

Common Over‑the‑Counter Choices

Loperamide (Imodium) is the go‑to OTC antidiarrheal. It slows gut movement, so stools become firmer. The usual adult dose is 2 mg after the first loose stool, then 2 mg after each subsequent loose stool, not exceeding 8 mg in 24 hours. If you have a fever, blood in stool, or severe abdominal pain, skip loperamide and see a doctor.

Bismuth subsalicylate (Pepto‑Bismol) does more than stop diarrhea; it also eases nausea and mild stomach upset. Take 2 tablets (or 30 ml liquid) every 30‑60 minutes, up to eight doses a day. It can turn your tongue black—nothing to worry about, but stop if you develop ringing in your ears or allergic signs.

Prescription Treatments & When to Use Them

For travelers battling bacterial diarrhea, rifaximin (Xifaxan) is a prescription option. It targets certain gut bacteria without major systemic effects. Typical adult dosing is 550 mg three times a day for three days. It’s not for infections caused by E. coli O157:H7 or for people with liver disease.

Diphenoxylate‑atropine (Lomotil) is another prescription antidiarrheal. It works like loperamide but stronger, and the tiny atropine dose discourages misuse. Start with 5 mg (two tablets) after the first loose stool, then 5 mg after each subsequent stool, limited to 40 mg per day. Reserve it for chronic diarrhea when OTC meds fail.

When diarrhea is caused by inflammation, such as in ulcerative colitis, doctors may prescribe mesalamine or steroids. These aren’t simple antidiarrheals; they treat the underlying inflammation. Always follow the exact prescription instructions and never stop steroids abruptly.

Even the best meds won’t help if you’re dehydrated. Replace fluids with water, oral rehydration solutions, or clear broths. Aim for at least 1 L of fluid per hour if diarrhea is severe. Kids need even more careful monitoring—use pediatric doses and consider calling a pediatrician quickly.

Side effects can pop up with any diarrhea drug. Loperamide may cause constipation, dizziness, or dry mouth. Bismuth can cause constipation or dark stools. Rifaximin’s rare side effects include nausea and headache. If you notice severe abdominal cramps, bloating, or persistent vomiting, stop the medication and seek medical help.

When should you see a doctor? If diarrhea lasts longer than two days for adults (or 24 hours for kids), if you have blood, high fever, severe pain, signs of dehydration, or a chronic condition like Crohn’s disease, get professional advice. Prompt treatment can prevent complications.

Bottom line: use OTC meds for mild, short‑term bouts, but don’t ignore warning signs. Prescription options exist for travelers, chronic cases, or infections that need targeted therapy. Stay hydrated, follow dosing rules, and call a healthcare provider when in doubt. With the right approach, you’ll get back to feeling normal fast.